Reply to Swenson: Balanced Crystalloid versus Saline Solution in Critically Ill Patients: Is Chloride the Villain?

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Balanced Crystalloids versus Saline in Critically Ill Adults.

BACKGROUND Both balanced crystalloids and saline are used for intravenous fluid administration in critically ill adults, but it is not known which results in better clinical outcomes. METHODS In a pragmatic, cluster-randomized, multiple-crossover trial conducted in five intensive care units at an academic center, we assigned 15,802 adults to receive saline (0.9% sodium chloride) or balanced c...

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Balanced Crystalloids versus Saline in Noncritically Ill Adults.

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Hypertonic versus isotonic crystalloid for fluid resuscitation in critically ill patients.

BACKGROUND Hypertonic solutions are considered to have a greater ability to expand blood volume and thus elevate blood pressure and can be administered as a small volume infusion over a short time period. On the other hand, the use of hypertonic solutions for volume replacement may also have important disadvantages. OBJECTIVES To determine whether hypertonic crystalloid decreases mortality in...

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ژورنال

عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine

سال: 2019

ISSN: 1073-449X,1535-4970

DOI: 10.1164/rccm.201904-0859le